GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7267979 | 1 | rs6138575 | chr20:25438952 | FAM182B | chr20:25744102-25848786:- | 0.25 | 5.08 | 5.38E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6138575 | chr20:25438952 | NINL | chr20:25433338-25566153:- | -0.37 | -7.57 | 1.93E-13 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs965469 | 1 | rs6139064 | chr20:3277050 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.92 | 6.32E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6139068 | chr20:3284393 | ITPA | chr20:3190056-3204504:+ | -0.25 | -6.07 | 2.6E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6139088 | chr20:3329063 | ITPA | chr20:3190056-3204504:+ | -0.23 | -5.69 | 2.21E-8 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6139103 | chr20:3361140 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.87 | 8.02E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6139117 | chr20:3387785 | ITPA | chr20:3190056-3204504:+ | -0.28 | -6.72 | 5.28E-11 | IFN-related cytopenia |
| THCA | cis | rs943466 | 1 | rs61394483 | chr6:33751945 | LEMD2 | chr6:33738991-33756906:- | 0.25 | 5.02 | 7.4E-7 | Body mass index |
| THCA | cis | rs4888671 | 1 | rs61402842 | chr16:77780398 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.99 | 8.33E-7 | Obesity-related traits |
| THCA | cis | rs6141 | 1 | rs6141 | chr3:184090266 | PSMD2 | chr3:184017022-184026840:+ | 0.12 | 3.79 | 0.000172 | Platelet count;Diisocyanate-induced asthma |
| THCA | cis | rs6088813 | 1 | rs6141546 | chr20:33949282 | CEP250 | chr20:34042996-34099802:+ | -0.15 | -3.37 | 0.000804 | Height |
| THCA | cis | rs6088813 | 1 | rs6141546 | chr20:33949282 | CPNE1 | chr20:34213968-34262539:- | 0.3 | 5.95 | 5.17E-9 | Height |
| THCA | cis | rs6088813 | 1 | rs6141546 | chr20:33949282 | GDF5 | chr20:33897002-34042568:- | -0.18 | -3.81 | 0.000154 | Height |
| THCA | cis | rs6088813 | 1 | rs6141546 | chr20:33949282 | UQCC | chr20:33890383-33999833:- | 0.32 | 10.23 | 2.48E-22 | Height |
| THCA | cis | rs6088813 | 1 | rs6141548 | chr20:33971085 | CEP250 | chr20:34042996-34099802:+ | -0.15 | -3.37 | 0.000804 | Height |